Livestock health and productivity are negatively impacted by the presence of endemic and emerging diseases, increasing the amount of resources needed to maintain these animals, which in turn increases competition for land, air and water. In response, hundreds of millions of dollars are invested globally on disease mitigation in order to improve livestock health and productivity, yet a systematic process to determine the burden of animal disease on the health and wellbeing of people is not available. It is unknown how the burden is apportioned between smallholders and the commercial sector, by region and gender. Consequently, decision makers lack the information to accurately assess whether their investments target the animal health issues that have the most significant impact on human wellbeing.